Growth Rate Manipulation of Brain Organoid Using Mini RFID Chip

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Erick Jones
Marci Henry
Dhruvi Rajput
Rheygan Reed
Terrence Frazier
Edidiong Inyang
Syeda Hossain
Micheal Cho
Felicia Jefferson

Abstract

An estimated 6.7 million Americans, age 65 and older, are living with Alzheimer's in 2023, which destroys the neurons and their connections in parts of the brain that are involved in memory (the amygdala, hippocampus, cerebellum, and the prefrontal cortex). The possibility of inducing the growth of the neurons in an adult brain can be therapeutic.  Alzheimer’s Disease (AD) pathology could be replicated in induced PSC-derived neurons developed in brain organoids complex 3-D bioengineered tools for studying neurodegenerative diseases. Our hypothesis is that the electrical signals can increase the neuron cell growth and enhance the connectivity between neurons Our research proposes growing a brain organoid around a functional RFID chip and testing the effects of RFID on neurons, and the ability to use RF to stimulate de novo neuron growth as a potential therapeutic to enhancing memory for patients with AD.   Here we describe a successful completion of the first phase growing astrocytes, essential glial cells in synapse formation and maturity of neural networks, around an RFID chip and retaining the ability to receive signals. 

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